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Symbol Name ID |
Fbxw7
F-box and WD-40 domain protein 7 MGI:1354695 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Neutropenia |
| Disease(s) Associated with FBXW7 | |
| developmental delay, hypotonia, and impaired language |
| Mouse Phenotypes | hematopoietic system phenotype |
increased T cell apoptosis |
enlarged thymus |
thymus hypoplasia |
abnormal T cell differentiation |
decreased double-negative T cell number |
increased double-positive T cell number |
arrested T cell differentiation |
decreased bone marrow cell number |
abnormal erythrocyte cell number |
decreased single-positive T cell number |
decreased hematopoietic stem cell number |
abnormal T cell activation |
abnormal hematopoietic stem cell physiology |
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| Availability | Mouse Genotype | ||||||||||||||
| Fbxw7tm1Sje/Fbxw7tm1Sje | |||||||||||||||
| Fbxw7tm1Iaai/Fbxw7tm1Iaai Tg(Mx1-cre)1Cgn/0 (conditional) |
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| Fbxw7tm1Kei/Fbxw7tm1Kei Tg(Lck-cre)1Cwi/? (conditional) |
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| Fbxw7tm1Kei/Fbxw7tm1Kei Tg(Cd4-cre)1Cwi/? (conditional) |
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| Fbxw7tm2Iaai/Fbxw7+ Tg(Mx1-cre)1Cgn/0 (conditional) |
* | ||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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